Epigenetics - A role in Cancer
"Indeed, the overexpression of HDACs has been linked to key events of tumorigenesis such as the epigenetic repression of the tumor suppressor gene CDKN1A (encoding the cyclin-dependent kinase inhibitor p21waf1/cip1; ref. 13) and key genes encoding DNA damage repair enzymes such as breast cancer 1, early onset (BRCA1) and ataxiatelangiectasia and Rad3 related (ATR ) (14). However, it is clear that HDAC overexpression is not always a negative prognostic marker;" .....Read more below!